Gene Expression Profiling in the Cortex of Fabp4 Knockout Mice.

ABSTRACT:

Aims

Fatty acid binding protein 4, adipocyte (Fabp4), is well known for its role in peripheral lipid metabolism, but its potential role in brain function remains largely unexplored. This study aimed to investigate Fabp4 expression in the adult mouse brain and explore gene expression changes in Fabp4 knockout (KO) mice to assess its potential impact on brain function.

Methods

We conducted in situ hybridization to assess Fabp4 expression in key brain regions of adult mice. In parallel, differential gene expression analysis using RNA-seq was conducted in the prefrontal cortex of Fabp4 KO mice to identify genes affected by Fabp4 deficiency.

Results

No Fabp4 expression was detected in the brains of mice, suggesting a lack of direct involvement in the central nervous system

SUBMITTER: Kirikae H 

PROVIDER: S-EPMC11806211 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature