FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis.

ABSTRACT: IL-17A plays an important role in the pathology of psoriasis and psoriatic arthritis (PsA). However, the pathogenic association between the skin and joint manifestations in PsA is not completely understood. In this study, we initially observed that IL-17A and FGF7 induced endochondral ossification in the mouse entheseal histoculture. Importantly, the responses of endochondral ossification by IL-17A stimulation were strongly inhibited by the treatment of a blocking antibody to FGF receptor 2IIIb, which is the receptor of FGF7, suggesting that FGF7 acts as a downstream factor of IL-17A in the endochondral ossification in the culture. Next, using the animal PsA model, the administration of an anti-FGF receptor 2IIIb antibody resulted in significant suppression of ankylosing enthesitis but not

SUBMITTER: Ebihara S 

PROVIDER: S-EPMC11806258 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature