Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis.

ABSTRACT:

Introduction and aims

Gastroesophageal reflux disease (GERD) and temporomandibular joint disorder (TMD) are relatively common conditions with a potential causal relationship. This study aims to investigate the possible causal relationship between GERD and TMD through bidirectional Mendelian randomization analysis.

Methods

Using data from large GWAS databases, we conducted bidirectional Mendelian randomization analyses to investigate the potential causal link between GERD and TMD. Instrumental variables were selected from the IEU platform, comprising 129,080 GERD cases and 473,524 controls from the UK Biobank. TMD data from the FinnGen project included 6,314 cases and 222,498 controls.

Results

The forward MR analysis suggested that GERD may increase the risk of TMD (OR

SUBMITTER: Gu R 

PROVIDER: S-EPMC11806311 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature