Cumulative Excess Body Mass Index and MGUS Progression to Myeloma.

ABSTRACT:

Importance

Obesity is a risk factor associated with multiple myeloma (MM) and its precursor, monoclonal gammopathy of unknown significance (MGUS). However, it is unclear how cumulative exposure to obesity affects the risk of MGUS progression to MM.

Objective

To determine the association of cumulative exposure to excess body mass index (EBMI), defined as BMI (calculated as weight in kilograms divided by height in meters squared) greater than 25, with risk of MGUS progression to MM.

Design, setting, and participants

This cohort study included patients with MGUS, including immunoglobin G, immunoglobin A, or light chain MGUS, from the nationwide US Veterans Health Administration database from October 1, 1999, to December 31, 2021. A published natural language processing-a

SUBMITTER: Liu L 

PROVIDER: S-EPMC11806393 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature