Structure-Function Relationships in Geographic Atrophy Based on Mesopic Microperimetry, Fundus Autofluorescence, and Optical Coherence Tomography.

ABSTRACT:

Purpose

To examine relationships between retinal structure and visual function in geographic atrophy (GA) by analyzing spatial agreement between absolute scotomas and macular structure, focusing on (1) choroidal hypertransmission, a key feature of complete retinal pigment epithelium and outer retinal atrophy (cRORA), and (2) fundus autofluorescence (FAF)-defined GA.

Methods

Mesopic microperimetry (using a novel T-shaped pattern) and multimodal imaging were recorded longitudinally in a phase II GA trial. Horizontal and vertical optical coherence tomography (OCT) line scans (corresponding to the T axes) were graded for choroidal hypertransmission; FAF images were graded for GA. Spatial concordance between zones of absolute scotoma and atrophy was quantified by the Dice similar

SUBMITTER: Mukherjee S 

PROVIDER: S-EPMC11806430 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature