Predicting cytomegalovirus infection and graft-versus-host disease using QuantiFERON-CMV and Monitor in pediatric transplants: a proof-of-concept study.

ABSTRACT:

Background

Cytomegalovirus (CMV) infection can lead to significant morbidity and mortality in pediatric hematopoietic stem cell transplant recipients. Early detection of CMV infection is crucial for managing its impact.

Aim

This study aims to evaluate the effectiveness of QuantiFERON-CMV^® (QF-CMV) and QuantiFERON-Monitor^® (QFM) tests in predicting CMV infection and graft-versus-host disease (GvHD) in pediatric hematopoietic stem cell transplant recipients to enhance patient outcomes and support personalized prevention strategies.

Methods

The QF-CMV and QFM tests were used to predict CMV pp65 antigen and GvHD in 24 pediatric hematopoietic stem cell transplant recipients.

Results

Data showed that positive CMV antigenemia (CMV-Ag) increased t

SUBMITTER: Souan L 

PROVIDER: S-EPMC11806478 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature