Roxadustat improves diabetic myocardial injury by upregulating HIF-1α/UCP2 against oxidative stress.

ABSTRACT:

Background

Diabetes mellitus (DM), characterized by hyperglycemia, is intricately linked with cardiovascular complications. Hyperglycemia induces oxidative stress, compromising mitochondria energy metabolism disturbances, leading to cardiomyocyte hypoxia and dysregulation of hypoxia-inducible factor-1α (HIF-1α), thereby exacerbating diabetic myocardial injury. Roxadustat (FG-4592), as an inhibitor of HIF-PHD, reduces HIF-1α degradation and regulates the transcription and function of downstream target genes. This study explores the protective effect of FG-4592 on the diabetic myocardium and further investigates the specific mechanisms responsible for this action.

Methods

We established diabetic myocardial injury mice and high glucose-induced rat cardiomyocyte models, administ

SUBMITTER: Fang T 

PROVIDER: S-EPMC11806548 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature