Genetic evidence for the liver-brain axis: lipid metabolism and neurodegenerative disease risk.

ABSTRACT:

Background

The liver‒brain axis is critical in neurodegenerative diseases (NDs), with lipid metabolism influencing neuroinflammation and microglial function. A systematic investigation of the genetic relationship between lipid metabolism abnormalities and ND, namely, Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), is lacking. To assess potential causal links between ND and six lipid parameters, two-sample Mendelian randomization (MR) was used.

Methods

Large-scale European ancestry GWAS data for lipid parameters and ND (AD, ALS, PD, and MS) were used. Genetic variants demonstrating significant correlations (P < 5 × 10^-8) with lipid metabolism parameters were identified and employed as instrumenta

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11806572 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature