Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes.

ABSTRACT:

Background

Skin ageing is influenced by complex genetic factors. Various phenotypes such as wrinkling, pigmentation changes, and skin cancers have been linked to specific genetic loci. However, the underlying genetic mechanisms and pathways remain poorly understood. This systematic review and meta-analysis aims to summarise the genetic loci found to be associated with skin ageing phenotypes by published genome-wide association studies (GWAS) and candidate gene studies. We also evaluated the overall association of loci via meta-analysis and identified the association patterns to explore potential biological pathways contributing to skin ageing. The Web of Science, Embase, and PubMed databases were searched on January 2024 using specific exclusion criteria (e.g., study of non-human s

SUBMITTER: Wong C 

PROVIDER: S-EPMC11806588 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature