Integrated analysis of dermatomyositis reveals heterogeneous immune infiltration and interstitial lung disease-associated endotype.

ABSTRACT:

Background

Dermatomyositis (DM) is an autoimmune disease with a high rate of disability and mortality especially in DM with concurrent interstitial lung disease (DM-ILD). Little is known about inflammatory signature and heterogeneous endotypes of DM.

Objective

We aimed to illustrate the systemic inflammatory signature of DM and define an ILD-associated endotype.

Methods

Olink proteomic analysis was performed on serum samples obtained from DM patients (n = 32), DM patients with ILD (n = 16), and healthy controls (n = 19). Transcriptomic data from skin samples was utilized to assess immune infiltration and investigate the correlation between protein and mRNA levels of biomarkers. Additionally, the prognostic value and clinical significance of identified biomarkers were

SUBMITTER: Xu X 

PROVIDER: S-EPMC11806601 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature