Blood molecular subtypes to guide precision treatment strategies in systemic juvenile idiopathic arthritis.

ABSTRACT:

Background

Systemic juvenile idiopathic arthritis (sJIA) is the most severe subtype of JIA, with a combination of diverse clinical manifestations and a variable clinical course. A comprehensive understanding of molecular signatures at the systems level and the discovery of molecular subtypes are the initial steps toward personalized medicine in sJIA.

Methods

A blood transcriptomic dataset was collected from patients with systemic JIA (sJIA) (n = 168), polyarticular JIA (n = 254), oligoarticular JIA (n = 96), enthesitis-related arthritis (n = 40), and healthy controls (n = 220). Gene expression profiles were filtered for differentially expressed genes and unsupervised clustering, gene set enrichment, and network-based centrality analyses. The molecular signatures of three nov

SUBMITTER: Baek IW 

PROVIDER: S-EPMC11806610 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature