Acute kidney injury and outcomes in hospitalized children with autoimmune rheumatic disease.

ABSTRACT:

Background

Autoimmune rheumatic diseases (ARDs) in children can negatively impact renal function, potentially leading to acute kidney injury (AKI). This study compares the prevalence of AKI and other adverse in-hospital outcomes among hospitalized children with ARDs.

Methods

A retrospective analysis was conducted using the United States Nationwide Inpatient Sample (NIS) database from 2005 to 2020. The study included children aged 1-17 years with ARDs, categorized into inflammatory arthritis, ANCA-associated vasculitis, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and other connective tissue diseases. Logistic regression assessed associations between ARD types and outcomes, including AKI, dialysis, and major adverse events.

Results

Among 13,891 childre

SUBMITTER: Lin CH 

PROVIDER: S-EPMC11806621 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature