High risk for life-threatening adverse events of fluoroquinolones in young adults: a large German population-based cohort study.

ABSTRACT:

Background

Fluoroquinolone antibiotics have a high potential for serious adverse drug reactions, but real-world evidence in European patient cohorts is lacking. Therefore, we aim to examine the association between fluoroquinolone exposure and potentially life-threatening adverse events stratified by age and gender in Germany.

Methods

We conducted an administrative cohort study using the active comparator new user design with a risk window up to 365 days between January 2013 and December 2019. Population-based longitudinal data from one of the largest German statutory health insurances were used. Episodes of newly dispensed fluoroquinolones (ciprofloxacin, levofloxacin, ofloxacin, moxifloxacin, norfloxacin, and enoxacin) were compared to other antibiotics (amoxicillin, amoxic

SUBMITTER: Wicherski J 

PROVIDER: S-EPMC11806691 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature