Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution.

ABSTRACT:

Background

Single-cell transcriptomics has revolutionized tooth biology by uncovering previously unexplored areas. The mouse is a widely used model for studying human tissues and diseases, including dental pulp tissues. While human and mouse molars share many similarities, mouse incisors differ significantly from human teeth due to their continuous growth throughout their lifespan. The application of findings from mouse teeth to human disease remains insufficiently explored.

Methods

Leveraging multiple single-cell datasets, we constructed a comprehensive dental pulp cell landscape to delineate tissue similarities and species-specific differences between humans and mice.

Results

We identified a distinct cell population, Sfrp2^hi fibroblast progenitors, found

SUBMITTER: Zhao T 

PROVIDER: S-EPMC11806734 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature