Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi.

ABSTRACT:

Background

Anopheles stephensi is a competent malaria vector mainly present in southern Asia and the Arabian Peninsula. Since 2012, it has invaded several countries of eastern Africa, creating an emerging risk of urban transmission. Urgent efforts are required to develop novel and more efficient strategies for targeted vector control. CRISPR/Cas9-based homing gene drives have been proposed as attractive alternative strategies. Gene drives have the potential to spread a desired trait through a population at higher rates than via normal Mendelian inheritance, even in the presence of a fitness cost. Several target genes have been suggested and tested in different mosquito vector species such as Anopheles gambiae and Aedes aegypti. Several promising suppression drives have been develop

SUBMITTER: Larrosa-Godall M 

PROVIDER: S-EPMC11806748 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature