Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease.

ABSTRACT: To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IHD), the most prevalent pathological condition in human medicine, is induced by coronary artery narrowing, or occlusion, leading to bulk necrotic changes and fibrosis within the myocardium. Data associated with the pro-angiogenic activity of mitochondria have not been completely elucidated in terms of cardiac tissue regeneration. Here, we aimed to highlight the recent studies and advantages related to the application of mitochondrial mass in the ischemic myocardium. How and by which mechanisms, mitochondria can reduce aberrant myocardial tissue remodeling via different pathways such as angiogen

SUBMITTER: Hassanpour P 

PROVIDER: S-EPMC11806797 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature