Amniotic fluid microbiota and metabolism with non-syndromic congenital heart defects: a multi-omics analysis.

ABSTRACT:

Background and aims

Recent studies have indicated possible links between the microbiota and the fetal heart, while the relevant mechanism is still unknown. This study is aims to investigate whether analyzing the microbiota and metabolic profiles of amniotic fluid collected from pregnant women whose fetuses with or without non-syndromic congenital heart defects (CHDs), during the second and third trimester of pregnancy, could offer valuable insights into CHDs.

Methods and results

A case-control study was conducted with 17 cases diagnosed with non-syndromic CHDs (CHDs group) and 34 controls without congenital anomalies (control group) at a ratio of 1:2. The 16 S rDNA gene sequencing and metabolomics methods were employed to assess 51 amniotic fluid samples. The amniotic fluid

SUBMITTER: Xu W 

PROVIDER: S-EPMC11806881 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature