Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum.

ABSTRACT:

Background

RNA pesticide is regarded as the "third revolution in the history of pesticides". However, the double-stranded RNA (dsRNA) is easily degraded in the environment, and its delivery efficiency is not sufficient for pest management. This study aimed to construct a star polycation (SPc)-based delivery platform with strong protection and efficient delivery to develop a self-assembled RNA pesticide with dual RNA interference (RNAi) targets.

Results

The nanocarrier SPc was applied to assemble with dsRNA via electrostatic interaction, hydrogen bond and Van der Waals force, and the self-complexation with SPc formed nanoscale dsRNA/SPc complex. The SPc could protect the dsRNA from the degradation by midgut fluid or RNase A, thus significantly increasing the stability of dsRN

SUBMITTER: Qiao H 

PROVIDER: S-EPMC11806883 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature