Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease.

ABSTRACT:

Background

There is growing evidence that the pathogenesis of Alzheimer's disease is closely linked to the resident innate immune cells of the central nervous system, including microglia and astrocytes. Mitochondrial dysfunction in microglia has also been reported to play an essential role in the pathogenesis of AD and other neurological diseases. Therefore, finding the mitochondrial and immune-related gene (MIRG) signatures in AD can be significant in diagnosing and treating AD.

Methods

In this study, the intersection of the differentially expressed genes (DEGs) from the GSE109887 cohort, immune-related genes (IRGs) obtained from WGCNA analysis, and mitochondria-related genes (MRGs) was taken to identify mitochondria-immune-related genes (MIRGs). Then, using machine learnin

SUBMITTER: Meng T 

PROVIDER: S-EPMC11806906 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature