Perivascular glial reactivity is a feature of phosphorylated tau lesions in chronic traumatic encephalopathy.

ABSTRACT: Chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with repetitive head injuries, is characterised by perivascular hyperphosphorylated tau (p-tau) accumulations within the depths of cortical sulci. Although the majority of CTE literature focuses on p-tau pathology, other pathological features such as glial reactivity, vascular damage, and axonal damage are relatively unexplored. In this study, we aimed to characterise these other pathological features, specifically in CTE p-tau lesion areas, to better understand the microenvironment surrounding the lesion. We utilised multiplex immunohistochemistry to investigate the distribution of 32 different markers of cytoarchitecture and pathology that are relevant to both traumatic brain injury and neurodegeneration. We q

SUBMITTER: Osterman C 

PROVIDER: S-EPMC11807024 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature