Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing.

ABSTRACT:

Background

Colorectal cancer (CRC) is a molecularly heterogeneous disease, and its treatment and prognosis vary greatly among subgroups. Therefore, it is necessary to identify prognostic factors associated with the biological heterogeneity of CRC in order to improve patients' survival expectations.

Methods

We obtained and merged RNA-Seq data along with clinical details for colorectal cancer (CRC) from The Cancer Genome Atlas (TCGA) repository, and then performed immunocluster typing on all CRC specimens. We conducted differential expression gene (DEG) analysis, gene set enrichment analysis (GSEA), and tumor microenvironment (TME) analysis on CRC samples that were divided into high and low Immunity categories. Moreover, we pinpointed prognostic genes from immune-related gene

SUBMITTER: Huang A 

PROVIDER: S-EPMC11807041 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature