Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia.

ABSTRACT: There are several methods to improve cancer patient survival rates by inducing hyperthermia in tumor tissues, which involves raising their temperature above 41 °C. These methods utilize different energy sources to deliver heat to the target region, including light, microwaves or radiofrequency electromagnetic fields. We have developed a new, magnetically responsive nanocarrier, consisting of liposomes loaded with magnetic nanoparticles and cis-diamminedichloroplatinum (II) (CDDP), commonly known as Cisplatin. The resulting magnetoliposome (ML) is rapidly internalized by lung and pancreas tumor cell lines, stored in intracellular vesicles, and capable of inducing hyperthermia under magnetic fields. The ML has no significant toxicity both in vitro and in vivo and, most importantly, enhances

SUBMITTER: Jimenez-Lopez MC 

PROVIDER: S-EPMC11807125 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature