USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer.

ABSTRACT: Metastasis is a major challenge for colorectal cancer (CRC) treatment. In this study, we identified autophagy activation as a prognostic indicator in CRC and observed that the expression of key autophagy proteins is elevated in metastatic and recurrent cases. Our subsequent goal was to identify potential genes associated with the autophagy panel and assess their prognostic significance, biological roles, and mechanisms in CRC metastasis. Among the candidates, CENPF emerged as the top gene in our screening process. We found that CENPF expression was preferentially elevated in CRC tissues compared to adjacent normal tissues, with significantly higher levels in CRC patients with tumor recurrence. Furthermore, a multicenter cohort study demonstrated that upregulated CENPF expression was strong

SUBMITTER: Xie Z 

PROVIDER: S-EPMC11807140 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature