Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation.

ABSTRACT: Neuronal differentiation and maturation are crucial for developing research models and therapeutic applications. Brain-derived neurotrophic factor (BDNF) is a widely used biochemical stimulus for promoting neuronal maturation. However, the broad effects of biochemical stimuli on multiple cellular functions limit their applicability in both in vitro models and clinical settings. Electrical stimulation (ES) offers a promising physical method to control cell fate and function, but it is hampered by lack of standard and optimised protocols. In this study, we demonstrate that ES outperforms BDNF in promoting neuronal maturation in human neuroblastoma SH-SY5Y. Additionally, we address the question regarding which ES parameters regulate biological responses. The neuronal differentiation and matur

SUBMITTER: Diego-Santiago MDP 

PROVIDER: S-EPMC11807145 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature