Single cell transcriptome profiling reveals pathogenesis of bullous pemphigoid.

ABSTRACT: Bullous pemphigoid (BP) triggers profound functional changes in both immune and non-immune cells in the skin and circulation, though the underlying mechanisms remain unclear. In this study, we conduct single-cell transcriptome analysis of lesional and non-lesional skin, as well as blood samples from BP patients. In lesional skin, non-immune cells upregulate pathways related to metabolism, wound healing, immune activation, and cell migration. LAMP3⁺DCs from cDC2 show stronger pro-inflammatory signatures than those from cDC1, and VEGFA⁺ mast cells, crucial for BP progression, are predominantly in lesional skin. As BP patients transition from active to remission stages, blood B cell function shifts from differentiation and memory formation to increased type 1 interferon

SUBMITTER: Liang G 

PROVIDER: S-EPMC11807148 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature