Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study.

ABSTRACT: Recombinant human growth hormone (rhGH) therapy is the primary treatment for children born small for gestational age (SGA) who fail to show spontaneous catch-up growth by two or four years. While its effects on white adipose tissue are well-documented, this pilot study aimed to investigate its impact on the lipidome and the thermogenic and endocrine activities of brown adipose tissue (BAT) in SGA children following rhGH treatment. The study involved 11 SGA children divided into two groups: (a) SGA children who were not treated with rhGH (n = 4) and (b) SGA children who received rhGH treatment with Saizen^® (n = 7). This second group of seven SGA children was followed for 12 months after initiating rhGH treatment. Interventions included 12-hour fasting blood extraction and infrare

SUBMITTER: Gonzalez L 

PROVIDER: S-EPMC11807155 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature