Severe COVID-19 disease is associated with genetic factors affecting plasma ACE2 receptor and CRP concentrations.

ABSTRACT: A hyperinflammatory state with highly elevated concentrations of inflammatory biomarkers such as C-reactive protein (CRP) is a characteristic feature of severe coronavirus disease 2019 (COVID-19). To examine a potential role of common genetic factors that may influence COVID-19 outcomes, we investigated whether individuals with a polygenic predisposition for a pro-inflammatory response (in the form of Polygenic Scores) are more likely to develop severe COVID-19. The innovative approach of polygenic scores to investigate genetic factors in COVID-19 severity should provide a comprehensive approach beyond single-gene studies. In our cohort of 156 patients of European ancestry, two overlapping Polygenic Scores (PGS) predicting a genetic predisposition to basal CRP concentrations were significa

SUBMITTER: Vogi V 

PROVIDER: S-EPMC11807156 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature