Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs.

ABSTRACT: Parasitic worm infections impose a significant public health burden, affecting over 2 billion people, particularly in low-income regions. The limited efficacy of current treatments highlights the urgent need for new anthelmintic agents. This study investigates the potential antiparasitic activity of 1,10-phenanthroline-5,6-dione (phendione) and its metal complexes, [Cu(phendione)₃](ClO₄)₂.8H₂O and [Ag(phendione)₂](ClO₄), against Schistosoma mansoni, the causative agent of intestinal schistosomiasis, and Angiostrongylus cantonensis, responsible for eosinophilic meningitis in humans. Additionally, the compounds were tested on Caenorhabditis elegans, a model organism for drug discovery. All compounds exhibited strong antiparasi

SUBMITTER: Cirino ME 

PROVIDER: S-EPMC11807182 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature