Large-scale prospective serum metabolomic profiling reveals candidate predictive biomarkers for suspected preeclampsia patients.

ABSTRACT: Preeclampsia (PE) is a serious pregnancy complication that contributes to maternal and perinatal morbidity and mortality. Understanding its pathogenesis and revealing predictive biomarkers are essential for guiding treatment decisions. In order to explore the global changes of serum metabolites in PE patients and identify potential predictive biomarkers for suspected PE patients (pregnant women who had already shown PE-related symptoms in the middle to late stages of pregnancy, but were not yet confirmatively diagnosed as PE.), a large-scale serum metabolomic analysis was conducted in this study with a prospective cohort of 328 suspected PE patients in the middle or late pregnancy stages, as well as a retrospective cohort of 30 healthy pregnant women and 30 PE patients. Using liquid chroma

SUBMITTER: Cao Y 

PROVIDER: S-EPMC11807192 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature