Nomogram Prediction of Response to Neoadjuvant Chemotherapy Plus Pembrolizumab in Locally Advanced Hypopharyngeal Squamous Cell Carcinoma.

ABSTRACT:

Importance

The objective response (ORR) rate in patients with locally advanced hypopharyngeal squamous cell-carcinoma (LA-HPSCC) following neoadjuvant chemotherapy (NACT) of albumin-bound paclitaxel plus carboplatin is low. At present, it is unclear whether the addition of pembrolizumab could increase the ORR or not.

Objective

To investigate whether the addition of pembrolizumab could increase the ORR, and to develop a nomogram to predict the response of pembrolizumab addition.

Design

Retrospective cohort study.

Setting

This study was conducted at a single institution.

Participants

This study included 129 patients who conformed to the inclusion criteria.

Intervention or exposures

NACT with or without pembrolizumab for patients with LA-HPSCC.

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SUBMITTER: Hu Z 

PROVIDER: S-EPMC11807280 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature