Joint Regional Uptake Quantification of Thorium-227 and Radium-223 Using a Multiple-Energy-Window Projection-Domain Quantitative SPECT Method.

ABSTRACT: Thorium-227 ( )-based -particle radiopharmaceutical therapies ( -RPTs) are currently being investigated in several clinical and pre-clinical studies. After administration, decays to , another -particle-emitting isotope, which redistributes within the patient. Reliable dose quantification of both and is clinically important, and SPECT may perform this quantification as these isotopes also emit X- and -ray photons. However, reliable quantification is challenging for several reasons: the orders-of-magnitude lower activity compared to conventional SPECT, resulting in a very low number of detected counts, the presence of multiple photopeaks, substantial overlap in the emission spectra of these isotopes, and the image-degrading effects in SPECT. To address these issues, we propose a multiple-ene

SUBMITTER: Li Z 

PROVIDER: S-EPMC11807287 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature