Preoperative prediction of IDH genotypes and prognosis in adult-type diffuse gliomas: intratumor heterogeneity habitat analysis using dynamic contrast-enhanced MRI and diffusion-weighted imaging.

ABSTRACT:

Background

Intratumor heterogeneity (ITH) is a key biological characteristic of gliomas. This study aimed to characterize ITH in adult-type diffuse gliomas and assess the feasibility of using habitat imaging based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) to preoperatively predict isocitrate dehydrogenase (IDH) genotypes and prognosis.

Methods

Sixty-three adult-type diffuse gliomas with known IDH genotypes were enrolled. Volume transfer constant (K^trans) and apparent diffusion coefficient (ADC) maps were acquired from DCE-MRI and DWI, respectively. After tumor segmentation, the k-means algorithm clustered K^trans and ADC image voxels to generate spatial habitats and extract quantitative image f

SUBMITTER: Wang X 

PROVIDER: S-EPMC11807326 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature