Treatment of stage I-III squamous cell anal cancer: a comparative effectiveness systematic review.

ABSTRACT:

Background

We sought to assess the effectiveness and harms of initial treatment strategies for stage I through III anal squamous cell anal cancer.

Methods

We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials between January 1, 2000, and March 2024, for randomized controlled trials and nonrandomized studies of interventions comparing initial treatment strategies. Individual study risk of bias and overall strength of evidence were evaluated for a prespecified outcome list using standardized methods.

Results

We identified 33 eligible studies and extracted data. Six were deemed low to moderate risk of bias. Compared with radiation therapy alone, chemoradiation therapy (CRT) with 5-fluorouracil (5-FU) and mitomycin C probably shows a benefit in l

SUBMITTER: Troester A 

PROVIDER: S-EPMC11807441 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature