Ontology highlight
ABSTRACT:
SUBMITTER: Habtemariam B
PROVIDER: S-EPMC1180745 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Habtemariam Bahru B Anisimov Victor M VM MacKerell Alexander D AD
Nucleic acids research 20050726 13
The Runt domain (RD) is the DNA-binding region of the Runx genes. A related protein, known as core binding factor beta (CBFbeta) also binds to the RD to enhance RD-DNA interaction by 6- to 10-fold. Here, we report results from molecular dynamics (MD) simulations of RD alone, as a dimer in complexes with DNA and CBFbeta and in a ternary complex with DNA and CBFbeta. Consistent with the experimental findings, in the presence of CBFbeta the estimated free energy of binding of RD to the DNA is more ...[more]