Screening and Antioxidant Activities Evaluation of Peptides From Abalone (Haliotis discus hannai Ino).

ABSTRACT: Marine organisms are rich in antioxidant peptides; however, extracting these peptides is time-consuming, labor-intensive, and costly, with sequence losses leading to uncertain results. This study aimed to identify abalone-derived antioxidant peptides with strong Keap1 binding ability and validate their antioxidative activities using a cellular oxidative damage model. We constructed an abalone-derived peptide library comprising 363 peptides using virtual enzymatic hydrolysis techniques. Of the 98 human Keap1 protein structures available in the protein data bank database, 2FLU was selected as the receptor. Using the CDOCKER module in Discovery Studio software, molecular docking was performed with the peptide library as ligands and 2FLU as the receptor, targeting the binding site at coordinat

SUBMITTER: Wu J 

PROVIDER: S-EPMC11807725 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature