Discovery of Novel Pain Regulators Through Integration of Cross-Species High-Throughput Data.

ABSTRACT:

Aims

Chronic pain is an impeding condition that affects day-to-day life and poses a substantial economic burden, surpassing many other health conditions. This study employs a cross-species integrated approach to uncover novel pain mediators/regulators.

Methods

We used weighted gene coexpression network analysis to identify pain-enriched gene module. Functional analysis and protein-protein interaction (PPI) network analysis of the module genes were conducted. RNA sequencing compared pain model and control mice. PheWAS was performed to link genes to pain-related GWAS traits. Finally, candidates were prioritized based on node degree, differential expression, GWAS associations, and phenotype correlations.

Results

A gene module significantly over-enriched with the pain ref

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11807727 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature