Association between vitamin D deficiency and major depression in patients with chronic kidney disease: a cohort study.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) have an elevated risk of both vitamin D deficiency (VDD) and depression. However, the relationship between VDD and the risk of depression in this population remains unclear.

Methods

Using the TriNetX network database (2010-2019), we conducted a propensity score-matched cohort study of CKD patients aged ≥50 years. Patients were categorized into VDD (≤20 ng/mL) and control (≥30 ng/mL) groups based on measurements within 3 months of CKD diagnosis. The primary outcome was the incidence of major depression within 1 year of follow-up.

Results

Among 17,955 matched pairs, VDD was associated with increased depression risk at 1 year (hazard ratio [HR]: 1.929; 95% confidence interval [CI]: 1.52-2.448; p < 0.0001). This

SUBMITTER: Chen IW 

PROVIDER: S-EPMC11807813 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature