White-Matter Structural Connectivity and Alzheimer's Disease: A Mendelian Randomization Study.

ABSTRACT:

Background

Alzheimer's disease (AD) and white-matter structural connectivity have been linked in some observational studies, although it is unknown if this is a causal relationship. The purpose of this study was to examine the impact of various white-matter structural connectivity on AD via a two-sample multivariate Mendelian randomization (MR) approach.

Methods

The genome-wide association study (GWAS) of Wainberg et al. provided the summary data on white-matter structural connectivity, and Bellenguez et al.'s study provided the GWAS aggregated data for AD. MR methods included inverse variance weighted, Mendelian randomization Egger, simple mode, weighted median, and weighted mode. Heterogeneity, horizontal pleiotropy, and "leave-one-out" analysis guaranteed the robustness o

SUBMITTER: Liu S 

PROVIDER: S-EPMC11807845 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature