Genetic variants associated with chronic fatigue syndrome predict population-level fatigue severity and actigraphic measurements.

ABSTRACT:

Study objectives

The diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (CFS) is based on a constellation of symptoms which center around fatigue. However, fatigue is commonly reported in the general population by people without CFS. Does the biology underlying fatigue in patients with CFS also drive fatigue experienced by individuals without CFS?

Methods

We used UK Biobank actigraphy data to characterize differences in physical activity patterns and daily temperature rhythms between participants diagnosed with CFS compared to controls. We then tested if single nucleotide variants (SNVs) previously associated with CFS are also associated with the variation of these actigraphic CFS correlates and/or subjective fatigue symptoms in the general population.

Result

SUBMITTER: Liu PZ 

PROVIDER: S-EPMC11807886 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature