Superoxide is an Intrinsic Signaling Molecule Triggering Muscle Hypertrophy.

ABSTRACT: Aims: Redox signaling plays a key role in skeletal muscle remodeling induced by exercise and prolonged inactivity, but it is unclear which oxidant triggers myofiber hypertrophy due to the lack of strategies to precisely regulate individual oxidants in vivo. In this study, we used tetrathiomolybdate (TM) to dissociate the link between superoxide (O₂^•-) and hydrogen peroxide and thereby to specifically explore the role of O₂^•- in muscle hypertrophy in C2C12 cells and mice. Results: TM can linearly regulate intracellular O₂^•- levels by inhibition of superoxide dismutase 1 (SOD1). A 70% increase in O₂^•- levels in C2C12 myoblast cells and mice is necessary and sufficient fo

SUBMITTER: Lu S 

PROVIDER: S-EPMC11807898 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature