Identification of mitophagy-related genes impacting patient survival in glioma.

ABSTRACT:

Background

This study presents a new prognostic model using mitophagy-related genes (MRGs) in glioma, a type of brain tumor, developed through bioinformatics. The model seeks to improve the understanding of glioma prognosis by focusing on mitophagy, a cellular process that eliminates damaged mitochondria and influences tumor behavior and patient outcomes.

Methods

The expression profile and clinical information of patients were downloaded from TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus). By analyzing the correlation between the 14 MRGs and glioma prognosis, we established a novel prognostic model in the TCGA training cohort and validated it in the GSE16011 dataset.

Results

Using univariate Cox regression, we identified 26 MRGs that were significant

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11807950 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature