The gut-kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity.

ABSTRACT:

Introduction

Chronic nephrotoxicity caused by CNIs (CICN) manifests clinically as chronic kidney disease (CKD). Astragaloside IV (AS-IV) plays a certain role in the treatment of CKD. This study aimed to verify the ameliorative effects of AS-IV on CICN and further explore the mechanisms underlying the modulation of the "gut-transcriptome-metabolome coexpression network" by AS-IV within the context of the "gut-kidney axis" to improve CICN.

Methods

Five groups of 40 mice were studied: a normal group (N, olive oil), a model group (M, CsA, 30 mg kg^--1 d^-1), a low-dose AS-IV group (CsA + AS-IV, 30 mg kg^-1 d^-1 + 10 mg kg^-1 d^-1), a high-dose AS-IV group (CsA + AS-IV, 30 mg kg^-1 d^-1 + 20 mg kg

SUBMITTER: Han C 

PROVIDER: S-EPMC11807982 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature