Proteomic and serologic assessments of responses to mRNA-1273 and BNT162b2 vaccines in human recipient sera.

ABSTRACT:

Introduction

The first vaccines approved against SARS-CoV-2, mRNA-1273 and BNT162b2, utilized mRNA platforms. However, little is known about the proteomic markers and pathways associated with host immune responses to mRNA vaccination. In this proof-of-concept study, sera from male and female vaccine recipients were evaluated for proteomic and immunologic responses 1-month and 6-months following homologous third vaccination.

Methods

An aptamer-based (7,289 marker) proteomic assay coupled with traditional serology was leveraged to generate a comprehensive evaluation of systemic responsiveness in 64 and 68 healthy recipients of mRNA-1273 and BNT162b2 vaccines, respectively.

Results

Sera from female recipients of mRNA-1273 showed upregulated indicators of inflammatory and

SUBMITTER: Hickey TE 

PROVIDER: S-EPMC11808009 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature