Pupillometric and perceptual approaches provide independent estimates of melanopsin activity in humans.

ABSTRACT:

Study objectives

Melanopsin-expressing retinal ganglion cells, which provide light information to time sleep and entrain circadian clocks, also influence perceived brightness raising the possibility that psychophysical paradigms could be used to explore the origins and implications of variability in melanopic sensitivity. We aimed to develop accessible psychophysical tests of melanopic vision and relate outcomes with a pupillometric measure of melanopsin function (post-illumination pupil response) and prior light exposure.

Methods

Individually calibrated pairs of isoluminant stimuli differing in melanopic radiance from a four primary source were presented sequentially with superimposed random color offsets in a two alternative forced choice brightness preference paradigm to

SUBMITTER: Woelders T 

PROVIDER: S-EPMC11808064 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature