Novel susceptibility genes and biomarkers for obstructive sleep apnea: insights from genetic and inflammatory proteins.

ABSTRACT:

Study objectives

Numerous observational studies link obstructive sleep apnea (OSA) to inflammatory proteins, yet the directionality of these associations remains ambiguous. Therefore, we aimed to clarify the potential associations of gene-predicted inflammatory proteins with OSA.

Methods

Based on genome-wide association study data, we applied Mendelian randomization (MR) to explore potential connections between circulating inflammatory proteins and OSA, primarily using the inverse-variance weighting method for robustness. Cochran's Q test, MR‒Egger intercept test, MR-PRESSO, and leave-one-out method were used to perform sensitivity tests for pleiotropy and heterogeneity. Replication analyses and meta-analyses were performed using other independent data. Steiger tests and mul

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11808066 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature