FBN2 promotes the proliferation, mineralization, and differentiation of osteoblasts to accelerate fracture healing.

ABSTRACT: Fracture is a disease in which the continuity of bone is interrupted or the integrity of bone is destroyed due to various reasons. It can be life-threatening when severe fractures occur. The RNA-seq datasets related to 'fracture' were screened and the common differentially expressed genes (DEGs) were determined. Protein-protein interaction network was constructed to identify hub genes. The fracture mice model was constructed and HE staining was performed to observe the histological characteristics of fracture. The expression of inflammatory factors and hub genes were evaluated by ELISA and qRT-PCR. CCK-8 assay, flow cytometry and Alizarin Red S staining were performed to evaluate the effects of fibrillin2(FBN2) on viability, apoptosis and mineralization of MC3T3E1 cells, respectively. West

SUBMITTER: Huang J 

PROVIDER: S-EPMC11808093 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature