Phenotypic and genotypic characterization of Candida parapsilosis complex isolates from a Lebanese hospital.

ABSTRACT: The opportunistic pathogen Candida parapsilosis is a major causative agent of candidiasis leading to death in immunocompromised individuals. Azoles are the first line of defense in their treatment. The purpose of this study was to characterize eight fluconazole-resistant and sensitive C. parapsilosis hospital isolates through a battery of phenotypic tests that target pathogenicity attributes such as virulence, biofilm formation, stress resistance, and ergosterol content. Whole genome sequencing was carried out to identify mutations in key pathogenicity and resistance genes. Phylogenetic comparison was performed to determine strain relatedness and clonality. Genomic data and phylogenetic analysis revealed that two isolates were C. orthopsilosis and C. metapsilosis misidentified as C. paraps

SUBMITTER: El Hady R 

PROVIDER: S-EPMC11808099 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature