Transcriptome analysis reveals effects of ethynylestradiol and bisphenol A on multiple endocrine and metabolic pathways in the pituitary and liver of female Atlantic cod (<i>Gadus morhua</i>).

ABSTRACT:

Introduction

The pituitary and liver are among the main sites of action of estrogens in fish. Years of research has shown that xenoestrogens can interfere with functions of estrogens. There is however incomplete understanding of xenoestrogen targets genes, their molecular mechanisms and potential effects in some of the target organs, particularly the pituitary.

Methods

We performed a comprehensive analysis of pituitary and liver transcriptome 72 h after injection of ethynylestradiol (EE2: 10, 50 or 250 nmol/kg body weight/bw) and bisphenol A (BPA: 8, 40 or 200 μmol/kg bw) in juvenile female Atlantic cod (Gadus morhua).

Results

A broad range of reproductive and metabolic pathways were affected in both organs by BPA and EE2. In the pituitary, effects on the expre

SUBMITTER: Yadetie F 

PROVIDER: S-EPMC11808150 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature