Proliferative verrucous and homogeneous Leukoplakias exhibit differential methylation patterns.

ABSTRACT:

Objective

Proliferative verrucous leukoplakia (PVL) is considered a clinically distinct entity from other oral leucoplakias (OLs) due to its clinical presentation and evolution. However, molecular differences between them remain unclear. We aimed to determine whether there are methylation differences between PVL and other forms of OLs.

Materials and methods

Oral biopsies from 12 patients with PVL, eight patients with homogeneous leucoplakia (HL), and 10 healthy individuals were obtained for a genome-wide DNA methylation analysis via the Infinium EPIC Platform.

Results

A total of 1815 differentially methylated CpGs were found between PVL and HL, with a prominent state of hypermethylation in HL patients. CpGs covered 813 genes with distinct roles, including cell adhesio

SUBMITTER: Herreros-Pomares A 

PROVIDER: S-EPMC11808169 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature