Salivary calprotectin and neutrophils in inflammatory bowel disease in relation to oral diseases.

ABSTRACT:

Objective

Calprotectin is elevated in saliva from inflammatory bowel disease (IBD) patients, but it is also affected by oral disease. We assessed the salivary concentration of calprotectin in IBD patients, in relation to intestinal and oral diseases. Furthermore, we investigated the phenotype of salivary neutrophils from IBD patients, and their ability to secrete calprotectin.

Materials and methods

Thirty IBD patients and 26 controls were orally examined and sampled for stimulated saliva. Twenty-five IBD patients provided fresh fecal samples. Calprotectin concentrations in saliva and feces were determined by an enzyme-linked immunosorbent assay. Expression of CD11b, CD15, and CD16 on oral neutrophils was assessed by flow cytometry. Secretion of calprotectin was evaluated in

SUBMITTER: Majster M 

PROVIDER: S-EPMC11808171 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature